Fighting skin enemies

Published : 03/26/2019 12:44:40
Categories : News

Skin aging can be defined as a physiological process, chronic and progressive, which inevitably involves all individuals and which is linked to a series of metabolic factors and processes that cause damage to cellular structures.1

Sun exposure is a fundamental part, because it has beneficial effects on the body: production of vitamin D, which is essential for fixing calcium in bones, increased immune defenses and positive action on many aspects of daily health and well-being. On the other hand the effect of UVA and UVB rays on the skin results in an increase in the production of free radicals, potential damage to the skin and a decrease in the levels of hyaluronic acid, an important molecule in maintaining hydration and skin elasticity.

How to maintain skin hydration
Hyaluronic acid has been increasingly used as a food supplement to improve the skin. However, the effect of ingested hyaluronic acid may depend on its molecular weight because its physiological activities in the body vary with its molecular weight.
In one study, they examined the effects of ingested hyaluronic acid with different molecular weight on the skin. In this randomized, double-blind, placebo-controlled study, 61 subjects with dry skin received oral hyaluronic acid (120 mg / day), with two different molecular weights (300 kDa and 800 kDa) or placebo, for 6 weeks. The moisture content of the skin of the first two groups (receiving hyaluronic acid with different molecular weights) increased more in the group with greater molecular weight. A questionnaire on the symptoms of facial aging showed that the groups treated with hyaluronic acid showed a significant improvement in the skin condition compared to the placebo group.

In fact, hyaluronic acid is present in many tissues of the body and is essential for maintaining hydration and elasticity in the tissues of the skin, which contains about half the mass of hyaluronic acid in the body.
Due to its viscosity and its moisturizing effect, hyaluronic acid is widely distributed as a medicinal, cosmetic, food and, recently as a popular food supplement to promote skin wellbeing and aesthetics. The ingested hyaluronic acid contributes to its greater synthesis and also promotes cell proliferation in fibroblasts. 3
Hyaluronic acid is a molecule present in the connective tissues of the body, where it contributes to maintaining the state of hydration and elasticity of the skin, mucous membranes and joints. Its chemical structure is that of a high molecular weight linear mucopolysaccharide, able to bind to itself a high quantity of water molecules, thus bringing a high degree of hydration. This characteristic makes hyaluronic acid a fundamental molecule in maintaining tissue tonicity, because it is able to form a reticular structure with collagen fibers.

Hyaluronic acid is also useful at the joint level: it is in fact an important component of synovial fluid and cartilage, so it helps to cushion mechanical stress and maintain the right degree of lubrication and well-being of the joint.
Finally, high molecular weight hyaluronic acid has an antioxidant action, helping to neutralize free radicals and thus helping to combat the aging processes of the skin and other tissues.

The need to compensate for the physiological reduction of hyaluronic acid
The synthesis of hyaluronic acid and consequently its levels in the body physiologically decrease with age and with exposure to stressful factors such as pollutants, incorrect nutrition or UV rays, which contribute to an increase in free radicals and levels of oxidative stress in the body.
For this reason there are several situations in which it is important to compensate for the natural loss of hyaluronic acid, in order to maintain the well-being of skin, mucous membranes and joints.
In general, all the natural biochemical processes underlying the proper functioning of our body also produce waste metabolites, such as free radicals. Free radicals are unstable and reactive molecules that, accumulating inside the cells, can induce alterations in the DNA, in the lipids and in the proteins and a consequent progressive degeneration of the cells including those of the skin tissue. Skin aging is not only linked to an accumulation of free radicals, but also to another reaction involving sugars and proteins, known as glycation.

There is a vast literature on glycation that confirms this degenerative process linked to excess carbohydrates, which bind and denaturalize proteins and other substances throughout the body (brain, eye and skin in the first place). More and more, glycation is called into question as an extremely negative process, to be fought to improve the longevity of the human organism and therefore the great disease of chronic degenerative diseases. Among the most sensitive targets for the formation of AGE (advanced glycation end products), degradation products of this glycation process, there is the skin and in particular its fundamental constituent molecules such as elastin and collagen. The withering, the roughness, the hypotonus, the reduced elasticity and the dryness of the skin are all conditions that can be traced back to this excess of AGE, in turn a son of an excess of carbohydrates in nutrition and various other errors in lifestyle .
Carnosine is one of the most useful and scientifically validated molecules for positively interacting with the glycation process, for which nutraceuticals and dermocosmetic have recently introduced this active ingredient in higher quality and more innovative products.

Proeon ® has already promulgated a food supplement, Projaluseon®, consisting of a set of molecules, including high molecular weight hyaluronic acid (1600 KDalton) and of a high-dose vegatal origin (200 mg per dose). daily of two tablets), and high-dose carnosine (500 mg for two tablets daily), extremely targeted and beneficial for skin metabolism. This nutraceutical can be a valid support in the prevention and control of skin aging and more generally of cellular aging, thanks to the properties of its ingredients that act by reducing glycation, oxidative stress and increasing the heritage of hyaluronic acid.
In recent months, Proeon's dermocosmetic science has progressively led to the creation of high quality and extremely innovative serums and creams, based on the aforementioned concepts, but also combining the potentials of hyaluronic acid and carnosine4, those of the most interesting polyphenols such as maqui5 , amla6, hydroxytyrosol6. This is how the new dermocosmetic sons of the Proeon philosophy were born in the field of anti-aging science. These are products with local action on the face and body, based on innovative active ingredients already used to create our precious nutraceuticals and characterized by exceptional antioxidant capacities and marked "hormetic" activities, capable of stimulating through a beneficial stress "those healthy reactions that our body manages to generate in a completely natural way.

Thanks to the scientifically proven effects of these substances, you can check your skin for an effective rehydration and anti-wrinkle action.
The innovative formulation of Proeon dermocosmetics (Hydractive, Jalufive, Restitutiva and Eonskin) based on hyaluronic acid, carnosine and polyphenols, together with other scientifically tested substances, stimulates metabolism and skin regeneration, revitalizing the vital functions of skin cells and giving it tone, brightness and elasticity through a natural and effective anti-aging action.
In conclusion, the combination of a proven efficacious nutraceutical (Projaluseon) and innovative dermocosmetic based on scientifically innovative and validated concepts, is able to confer significant help to the well-being and aesthetics of the skin of the face and body, thus contributing to a more general healthy aging of the body.


  1. Hyaluronic acid, A key molecule in skin aging. Eleni Papakonstantinou, Michael Roth and George Karakiulakis Department of Pharmacology; School of Medicine; Aristotle University of Thessaloniki; Thessaloniki, Greece; 2Pulmonary Cell Research-Pneumology; University Hospital Basel; Basel, Switzerland
  1. Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. Chinatsu Kawada, Takushi Yoshida, Hideto Yoshida, Wakako Sakamoto, Wataru Odanaka, Toshihide Sato, Takeshi Yamasaki, Tomoyuki Kanemitsu, Yasunobu Masuda, and Osamu Urushibata. R&D Division, Kewpie Corporation, 2_5_7 Sengawa_cho, Chofu_shi, Tokyo 182_0002, Japan. Department of Dermatology, Toho University Ohashi Medical Center, 2_17_6 Ohashi, Meguro_ku, Tokyo 153_8515, Japan * (Received 23 June, 2014; Accepted 28 July, 2014; Published online 1 November, 2014)
  2. Ingested hyaluronan moisturizes dry skin. Chinatsu Kawada, Takushi Yoshida, Hideto Yoshida, Ryosuke Matsuoka, Wakako Sakamoto1, Wataru Odanaka, Toshihide Sato, Takeshi Yamasaki, Tomoyuki Kanemitsu, Yasunobu Masuda and Osamu Urushibata. Nutrition Journal 2014
  1. Carnosine as a Potential Anti-senescence Drug. S. Gallant, M. Semyonova, and M. Yuneva. Zoetic Neurosciences Ltd., Ivester Court, Wing Road, Leighton Buzzard, Beds, LU7 7NW, Great Britain; Department of Embriology, School of Biology, Lomonosov Moscow State University, Moscow, 119899 Russia; International Center for Biotechnology and Center of Molecular Medicine, Lomonosov Moscow State University (Department of Biochemistry), Moscow, 119899 Russia
  2.  Aristotelia chilensis: A Possible Nutraceutical or Functional Food. Jorge Peña Araos. Faculty of Health Sciences, Pedro de Valdivia University, Santiago, Chile
  3. A Polyphenol-Based Multicomponent Nutraceutical in Dysmetabolism and Oxidative Stress: Results froma Pilot Study. Roberto Corsi, MDa, Giovanni Mosti, MDb, Attilio Cavezzi, MDa, Simone Ugo Urso, MDa, Gayla Dimitrova, BSa, Elena Fioroni, MSc, Roberto Colucci, BSa, and Valentina Quinzi, MS. Eurocenter Venalinfa, San Benedetto del Tronto (AP), Italy; bClinic Barbantini, Lucca, Italy; cLaboratory Fioroni, San Benedetto del Tronto (AP), Italy

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