- Nutritional supplements
- Nutritional supplement packs
- Skin Cosmetics
- Clinical Areas
Last Product Reviews
Categories : News
Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being
by ENNIO GUAITOLINI, MD; ATTILIO CAVEZZI, MD; STEFANIA COCCHI, MD; ROBERTO COLUCCI, PhD; SIMONE UGO URSO, MD; and VALENTINA QUINZI, MD
Drs. Guaitolini, Cavezzi, Colucci, Urso, and Quinzi are with Eurocenter Venalinfa in San Benedetto del Tronto (AP), Italy. Drs.
Guaitolini and Cocchi are with the Studio Medico Guaitolini-Cocchi in Novellara (RE), Italy. Dr. Urso is with the Studio Medico Flebologico Zola in Predosa (BO), Italy.
J Clin Aesthet Dermatol. 2019;12(4):40–45
ABSTRACT: Objective. The purpose of this study was to evaluate the efficacy and safety of a multicomponent nutraceutical (MCN) on facial skin.
Methods. A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging. For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo. At Day 0 (T0) and Day 60 (T60), face skin hydration, elasticity, and sebometry were measured with an instrumental skin tester, and digital images of facial wrinkles were scored. A subject-based quali-/quantitative assessment evaluating satisfaction/quality of life was performed at T60.
Results. The MCN and placebo groups each included 25 volunteers (mean ages: 49.3 and 47.8 years, respectively). After 60 days of MCN intake, glabella skin hydration and elasticity improved by 15.2 percent and 22.6 percent, respectively (p=0.03; p=0.004), glabella sebaceous secretion decreased by 24.2 percent (p=0.01), skin hydration and elasticity of the periocular area increased by 12.6 percent and 15.9 percent, respectively, and skin hydration and elasticity of the oral commissural area increased by 17.6 percent and 16 percent, respectively (p<0.001). No significant variation occurred in the placebo group. Wrinkle depth improved slightly in the MCN group (p=0.043 in the periocular area) but not in the placebo group. A slight improvement in joint pain and mucosae/hair appearance was reported in the questionnaire in the MCN group only.
Conclusions. Our results suggest that MCN is safe and effective for facial skin aesthetics and well-being.
Link to the article published on the Journal of clinical and aestethic dermatology: http://jcadonline.com/nutraceutical-april-2019/
1. Puizina-Ivic N. Skin aging. Acta Dermatoven. 2008;17(2):47–54.
2. Gkogkolou P, Böhm M. Advanced glycation end products: key players in skin aging? Dermato-Endocrinology.2012;4(3):259–270
3. Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70.
4. Yagoda M, Gans E. A nutritional supplement formulated with peptides, lipids, collagen and hyaluronic acid optimizes key aspects of physical appearance in nails, hair and skin. J Nutr Food Sci. 2014;S5:002.
5. Proksch E, Segger D, Degwert J, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47–55.
6. Choi SY, Ko EJ, Lee YH, et al. Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. J Cosmet Laser Ther. 2014;16(3):132–137.
7. Di Cerbo A, Laurino C, Palmieri B, Iannitti T. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins. J Photochem Photobiol B. 2015; 144:94–103.
8. Papakonstantinou E, Roth M, Karakiulakis G Hyaluronic acid. A key molecule in skin aging. Dermatoendocrinol.2012;4(3):253–258.
9. Kawada C, Yoshida T, Yoshida H, et al. Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. J Clin Biochem Nutr. 2015;56(1):66–73.
10. Tashiro T, Seino S, Sato T, et al. Oral administration of polymer hyaluronic acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period. ScientificWorldJournal. 2012;2012:167928.
11. Reddy VP, Garrett MR, Perry G, Smith MA. Carnosine: a versatile antioxidant and antiglycating agent. Sci Aging Knowledge Environ. 2005;2005(18):pe12.
12. Budze? S, Rymaszewska J. The biological role of carnosine and its possible applications in medicine Adv Clin Exp Med. 2013;22(5):739–744.
13. Marí M, Morales A, Colell A, et al. Mitochondrial glutathione: a key survival antioxidant. Antioxid Redox Signal. 2009;11(11):2685–700.
14. Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med. 1992;13(5): 379–444.
15. Van der Merwe M, Bloomer RJ. The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise. J Sports Med. 2016;2016:7498359.
16. Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med. 2011;2011:528403.
17. Herane M, Fuenzalida H, Zegpi E, et al. Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase—a double-blind, randomized, placebo-controlled study J Cosmetic Dermatol.2009;8:181–185.
18. Rodríguez N, Sanz X, Dengra J, et al. Five-year outcomes, cosmesis, and toxicity with 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys.2013;87(5):1051–1057.
19. Goldberg L, Crysler C. A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with glisodin® Skin Nutrients Advanced Anti-Aging Formula. Clin Cosmet Investig Dermatol. 2014;7:139–144.
20. Arsiwala S, Tahiliani S, Jerajani H, Chandrashekhar Bs, Aurangabadkar S, et al. Evaluation of topical anti-wrinkle and firming (AWF) for women, antiwrinkle and firming (AFM) for men and deep wrinkles for wrinkles on face and neck. Asian J Pharm Clin Res. 2013;6(3):86–89.
21. Ekin M, Ya?ar L, Savan K, et al. The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Arch Gynecol Obstet. 2011;283(3):539–543.
22. De Luca C, Mikhal’chik EV, Suprun MV, et al. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid Med Cell Longev. 2016;2016:4389410.
23. Babizhayev MA, Deyev AI, Savel’yeva EL, et al. Skin beautification with oral non-hydrolized versions of carnosine and carcinine: effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging. J Dermatolog Treat. 2012;23(5):345–384.
24. Hipkiss AR, Baye E, de Courten B. Carnosine and the processes of ageing. Maturitas. 2016;93: 28–33.
25. Batres C, Kramer SS, DeAngelis CG, Russell R. Examining the “cosmetics placebo effect.” PLoS ONE. 2019;14(1): e0210238.
26. Babizhayev MA. Treatment of skin aging and photoaging with innovative oral dosage forms of nonhydrolized carnosine and carcinine. Int J Clin Derm Res. 2017;5(5):116–143.
27. Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: spplications and safety of a novel dietary supplement. Nutrients. 2017;9(3):290.
28. Amirshahrokhi K, Khalili AR. Methylsulfonylmethane is effective against gastric mucosal injury. Eur J Pharmacol.2017; 811:240–248.
29. Jung YR, Hwang C, Ha JM, et al. Hyaluronic acid decreases lipid synthesis in sebaceous glands. J Invest Dermatol. 2017;137(6):1215–1222.
30. Shanmugam S, Baskaran R, Nagayya-Sriraman S, et al. The effect of methylsulfonylmethane on hair growth promotion of magnesium ascorbyl phosphate for the treatment of alopecia. Biomol Ther. 2009,17(3):241–248.